Field experiments were conducted to evaluate the critical period for velvetleaf interference with cotton and to assess the reliability of using weed growth variables as predictors of cotton lint yield losses. An inverse linear relationship existed between velvetleaf dry weight and cotton lint yield. The relationship between the number of velvetleaf main-stem nodes or velvetleaf height with cotton lint yield was best described by quadratic regression equations. Weed dry weight appeared to be the most accurate predictor followed by weed height and by number of velvetleaf main-stem nodes. A nonlinear equation best described percent lint yield loss as a function of critical-period interference intervals.