Field experiments were conducted in 1985 and 1986 under eight environments to evaluate the population dynamics of a range of silverleaf nightshade densities and to measure the effects of those populations on cotton lint yield. Dry weed weights of silverleaf nightshade stands were influenced by growing conditions among years, but were positively related to initial densities as long as 2 yr after establishment. Stem numbers increased as initial densities and stand age increased. A negative linear relationship existed between cotton lint yield and weed biomass and between cotton lint yield and stem number from both 1- and 2-yr-old weed stands. For each 1 kg/10 m of row increase in dry weed weight from 1- and 2-yr-old stands, a 9 and 21% lint yield loss/ha was predicted, respectively. For each stem/10 m of row, a 0.35 and 0.31% yield loss was predicted, respectively. Late-planted cotton was less vulnerable to yield reductions by silverleaf nightshade; however, its yield potential was also less.