Field experiments were conducted to determine if aldicarb, disulfoton, or phorate applied in-furrow at 0.84 or 1.12 kg ai ha–1 affected cotton response to clomazone applied PPI or PRE at rates ranging from 0 to 1.12 kg ai ha–1. Disulfoton and phorate greatly reduced clomazone-induced chlorosis, stunting, and death of cotton seedlings. Compared with no insecticide or with dimethoate applied POST, aldicarb did not affect cotton response to clomazone. A clomazone rate by insecticide interaction was not observed for cotton yield. Clomazone reduced cotton yield at one of five locations. Insecticides affected yield at three locations, where highest yields were from cotton treated with aldicarb. In a separate experiment with 0.56, 1.12, and 2.24 kg ha–1 of phorate applied in-furrow and 1.12 kg ha–1 of clomazone applied PPI, phorate at all rates protected cotton from clomazone phytotoxicity.