Field studies were conducted in Arkansas in 1999, 2000, and 2001 to evaluate mesotrione applied preemergence (PRE) and postemergence (POST) for weed control in corn grown in the Mississippi Delta region of the United States. Mesotrione was applied PRE (140, 210, and 280 g/ha) alone and POST (70, 105, and 140 g/ha), alone or in tank mixtures with atrazine (280 g/ha). Standard treatments for comparison were S-metolachlor/atrazine PRE and S-metolachlor plus atrazine PRE followed by atrazine POST. All PRE treatments controlled velvetleaf, pitted morningglory, entireleaf morningglory, prickly sida, and broadleaf signalgrass 95% 2 wk after emergence (WAE). Mesotrione controlled velvetleaf 89% or more 4 and 6 WAE. Control of morningglory species by mesotrione POST averaged 92% 6 WAE. Prickly sida was controlled at least 90% by all treatments 4 WAE. Mesotrione applied alone PRE and POST controlled broadleaf signalgrass 83 to 91% 4 WAE. All treatments controlled broadleaf signalgrass less than 90% 6 WAE, except treatments that contained S-metolachlor, which gave 94% or greater control. Corn yield ranged from 10.5 to 12.4 Mg/ha and did not differ among treatments. Mesotrione PRE and POST provided excellent control of broadleaf weeds, but S-metolachlor was needed for broadleaf signalgrass control.