Field experiments were conducted in Missouri in 2004 through 2006 to compare the efficacy of fall and spring herbicide treatments for control of winter and summer annual weeds in no-tillage corn. Applications in the fall and 45 d before planting (45 PP) of 2,4-D and simazine; rimsulfuron, thifensulfuron, and 2,4-D; or glyphosate and 2,4-D controlled at least 90% of all winter annual weeds through 1 wk after corn planting (WAP), with a few exceptions. Applications made 30 d before planting (30 PP) of 2,4-D and glyphosate or rimsulfuron, thifensulfuron, and 2,4-D provided greater than 90% control of most winter annual weeds 1 WAP. Winter annual weed control was reduced with herbicide treatments applied 7 d before planting (7 PP), compared with earlier application timings. Summer annual weed control 5 WAP increased as the time between application and planting decreased. Fall applications resulted in greater weed biomass 5 WAP, compared with spring applications.