This paper is a first attempt to analyse the relationship between social protection systems and countries’ responses towards the regulation of platform work. It is argued that the degree of accessibility to social protection for self-employed workers is a predictor for how countries will deal with platform work. Countries that provide wide access to social protection for the self-employed tend to develop a more integrative response towards these work arrangements from a social protection perspective because the social protection of platform workers is a smaller policy challenge. On the other hand, in countries with a low degree of accessibility to social protection schemes, the response towards platform work is more confrontational. These responses are characterised by a larger number of court cases and legislative proposals because social protection for platform workers is a more pressing policy challenge and platform work arrangements are understood to be more antagonistic towards the respective social protection systems.