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1 results

  • Chapter 13 - Psychiatric aspects of Parkinson's disease

  • Edited by James J. Amos, University of Iowa, Robert G. Robinson, University of Iowa
  • Book:
    Psychosomatic Medicine
    Published online:
    04 August 2010
    Print publication:
    27 May 2010, pp 116-125

  • Summary

    To manage the agitated patient, it's critical to understand the origin of the behavior. This doesn't mean theorizing about the neurobiological underpinnings. Offering to inject the patient with an antipsychotic would not usually be welcomed as a first intervention. No specific medication is approved by the FDA for control of agitation and combative behavior. Droperidol is another very effective agent, although recent FDA black box warnings about the risk for cardiac arrhythmias and case reports of sudden death reported with its use have led to greater caution. Antipsychotics often provide non-specific but effective control of violent behavior regardless of its cause. Haloperidol is the most studied agent. Agitation of delirium is generally responsive to monotherapy with antipsychotics, and haloperidol is the agent with which physicians have the most experience and for which efficacy is best supported by the medical literature.