Neonatal aortic thrombosis is a rare occurrence but can be life-threatening. Most aortic thrombosis in neonates is related to umbilical artery catheters. A case of a neonate with a spontaneous aortic thrombosis is described here along with a comprehensive review of the literature for cases of neonatal aortic thrombosis not related to any intravascular device or procedure. The aetiologies of these spontaneous thromboses and the relevance of hypercoagulable disorders are discussed. The cases were analysed for odds of death by treatment method adjusted for era. The reference treatment method was thrombolysis and anticoagulation. No other treatment modality had significantly lower odds than the reference. Surgery alone had higher odds for death than the reference, but this may be confounded by severity of case. The management recommendations for clinicians encountering neonates with spontaneous neonatal aortic thrombosis are discussed.

This paper presents numerical results based on a macroscopic blood coagulation modelcoupled with a non-linear viscoelastic model for blood flow. The system of governingequations is solved using a central finite-volume scheme for space discretization and anexplicit Runge-Kutta time-integration. An artificial compressibility method is used toresolve pressure and a non-linear TVD filter is applied for stabilization. A simple testcase of flowing blood over a clotting surface in a straight 3D vessel is solved. This workpresents a significant extension of the previous studies [10] and [9].