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1 results

  • Chapter 14 - Sleep–Wake Disorders in Parkinson’s Disease

  • from Section 2: - Hypokinetic Movement Disorders
  • Edited by Erik Ch. Wolters, Universität Zürich, Christian R. Baumann, Universität Zürich
  • Book:
    International Compendium of Movement Disorders
    Published online:
    07 January 2025
    Print publication:
    06 February 2025, pp 166-180

  • Summary

    Sleep–wake disturbances belong to the most frequent non-motor symptoms in patients with Parkinson’s disease. They encompass insomnia, excessive daytime sleepiness, different forms of parasomnias, sleep-related breathing disorders, restless legs syndrome, and circadian sleep–wake disorders. All of these sleep–wake disorders have the potential to severely impact the quality of life of patients and their bedpartners, and some of them not only get more frequent with longer disease duration, but may even precede motor manifestations of Parkinson’s disease. Isolated REM sleep behavior disorder in particular is a specific biomarker heralding synuclein-related neurodegenerative disease. Although very common, both diagnostic and therapeutic approaches for Parkinson-related sleep–wake disorders are still under evaluation. This chapter discusses the current knowledge on the pathophysiology and clinical manifestations of Parkinson-related sleep–wake disorders, and contributes a clinical guide on how to diagnose and treat them.