Scale effects in cellular metals can develop when the specimen size is of the order of the cell size. Decreasing the relevant specimen dimensions—height, width, and ligament size (the region between notches in notched specimens)—leads to material strengthening in shear, in indentation, and in notched specimens and to reduced strength and stiffness in uniaxial compression. Experimental size-effect studies were reviewed, and it was concluded from discrete modeling results that scale effects are caused by two different microstructural mechanisms: boundary-layer effects and constraint effects. The first mechanism is active in shear (strong boundary layers) and uniaxial compression (weak boundary layers) and vanishes for specimens larger than two cell sizes and seven cell sizes, respectively. The second mechanism is active in indentation and in notched specimens, leading to a strengthening behavior that is inversely proportional to indenter and ligament size.