Time-specific life tables were constructed for the Mexican beetle, Zygogramma bicolorata Pallister (Coleoptera: Chrysomelidae), which is a promising biological control agent of the Neotropical weed, Parthenium hysterophorus L. (Asteraceae) in and around Bangalore, India. Infertility of eggs (46.00–71.10%) was found to be the key mortality factor, followed by death during the pupal stage (15.76–21.38%), as confirmed by key mortality factor analysis and construction of survivorship curves. No parasitoids or predators were recorded on this insect, while some of the dead pupae/pre-pupae (2.27–17.24%) were found to be infected by Metarhizium anisopliae (Metchnikoff) Sorokin. The high generation trend values (305.88–557.14), give an indication of the biotic potential of this insect, which was found to cause rapid defoliation of the weed under field conditions.