Bison is an important and iconic mammal in the U.S. that is being reintroduced in many places after being driven nearly to extinction. This paper provides a nationwide assessment of the local economic impacts of bison reintroduction so that rural communities can take economic well-being into account when considering decisions regarding future bison restorations. We estimate the causal impacts of bison herd establishment on county-level income, employment, and population growth using staggered difference-in-difference and the synthetic control approaches. The simple positive correlation between local per capita income and bison herds might lead planners to think that bison reintroduction is good for the local economy. However, none of the causal inference analyses find statistically significant effects of bison reintroduction.