Contact application of precocene 2 (6,7-dimethoxy-2,2-dimethylchromene) to inseminated adult female bed bugs inhibited egg maturation and affected egg viability. Third-stage nymphs exposed to 100μg/cm2 showed precocious maturation after the moult to the next stage. Nymphs exposed to lower concentrations of precocene exhibited teratism of the antennae, including the reduction of terminal sensillae. This was thought to be responsible for the bugs not assembling.
Reduction in the fecundity in adult bugs, and the morphogenetic and teratogenic activity in nymphs was circumstantially related to reduced levels of juvenile hormone, as a result of exposure to precocene.