The anterior cerebral artery (ACA) arises as the medial branch of the bifurcation of the internal carotid artery (ICA) at the level of the anterior clinoid process. The ACA supplies the whole of the medial surfaces of the frontal and parietal lobes, the anterior four-fifths of the corpus callosum, the frontobasal cerebral cortex, the anterior diencephalon, and other deep structures. Ischemic stroke in the ACA territory is most often the result of emboli from the heart or the ICA. Transient loss of consciousness has been described in patients with ACA territory infarctions, but it is uncommon; sustained unresponsiveness most often indicates abulia or akinetic mutism. Anterograde amnesia has been known to follow rupture and related surgery for an anterior communicating artery (ACoA) aneurysm. Distinct syndromes of callosal disconnection resulting from ACA territory infarctions include ideomotor apraxia, agraphia, and tactile anomia restricted to the left hand in right-handed patients.