This study formally links the literature on R&D-driven productivity growth to studies which examine GHG emission benefits from increased farm productivity growth. Using a global agricultural model and estimates from the literature, this study examines the impact of greater US public agricultural R&D spending over 2025−2035. The results show that roughly doubling public R&D investments in US agriculture could provide greater economic gains relative to its costs over the period 2017−2050. The GHG mitigation co-benefits from these investments also can be enhanced by combining R&D policies with strategies aimed at directly reducing farm inputs.