White yam (Dioscorea rotundata) is an important tuber crop in a number of countries, but especially in West Africa where it serves as a food staple as well as a cash crop as excess production is sold in local markets. But the availability of quality planting material, most notably seed yams, for yam production remains an important constraint for farmers. Techniques have been developed to help address this limitation by cutting yam tubers into pieces (minisetts), treating them with the pesticide either via a seed dressing dust or pesticide ‘dips’ and planting to grow seed yams of the required size and quality. But while there have been many studies on the agronomy and adoption by farmers of these techniques, there have been fewer studies on their economic performance. Indeed, to date there have been no studies that compare the economic performance of treating setts compared to leaving them untreated, and neither has there been any analysis of the environmental impact of treating setts. This paper reports the results of a study designed to address these two gaps in knowledge and is based upon results from a series of farmer-managed seed yam plots established in the middle belt of Nigeria over 4 years (2013–2016). Results suggest that revenue and gross margin were higher for treated versus untreated setts although the latter still performed relatively well. Using the Field Use Environmental Impact Quotient (EIQ), the commonly recommended pesticide sett treatments were estimated to have a low-to-moderate environmental impact, and further research is needed to see how far pesticide use can be reduced to still be effective and minimise any environmental impact.