A Von Neumann probe is a self-reproducing intelligent device with interstellar capabilities. A space-faring civilization could conceivably use such constructs to occupy much or all of the Milky Way galaxy and perhaps the entire universe. This paper presents several reasons that a civilization might decide to produce and deploy Von Neumann probes. Physically possible interstellar propulsion methods for such devices are discussed, as is a launch strategy minimizing the duration of an interstellar transfer. Various solar system locations could be investigated to determine whether Von Neumann probes are present in our vicinity.