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1 results

  • Increased vascular endothelial growth factor expression predicts a worse prognosis for laryngeal cancer patients: a meta-analysis

  • L-P Zhang, H-L Chen
  • Journal:
    The Journal of Laryngology & Otology / Volume 131 / Issue 1 / January 2017
    Published online by Cambridge University Press:
    08 December 2016, pp. 44-50
    Print publication:
    January 2017
  • Objective:

    This study assessed the relationship between vascular endothelial growth factor expression and the laryngeal cancer prognosis.

    Methods:

    Systematic computerised searches of PubMed were performed up to 31 January 2015. Prognostic endpoints were overall survival and disease-free survival. The pooled hazard ratios for overall survival and disease-free survival were also calculated.

    Results:

    Seven studies containing 975 patients were included. The pooled hazard ratio was 1.703 (95 per cent confidence interval, 1.373 to 2.112; z score = 4.85, p = 0.000) for overall survival and was 1.918 (95 per cent confidence interval, 1.410 to 2.609; z score = 4.15, p = 0.000) for disease-free survival. No significant publication bias was found. A sensitivity analysis showed that the results were robust. Power analyses also showed there was enough power to detect the calculated hazard ratios.

    Conclusion:

    The study found that vascular endothelial growth factor overexpression predicted a worse prognosis for laryngeal cancer patients. This supports a strategy of targeted therapy by blocking the vascular endothelial growth factor receptor.