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1 results

  • Effect of phosphodiesterase-5 inhibitor on hearing

  • S Okuyucu, O E Guven, E Akoglu, E Uçar, S Dagli
  • Journal:
    The Journal of Laryngology & Otology / Volume 123 / Issue 7 / July 2009
    Published online by Cambridge University Press:
    12 January 2009, pp. 718-722
    Print publication:
    July 2009
  • Objective:

    Following a report of sudden hearing loss in a patient taking phosphodiesterase type 5 inhibitor, and a Food and Drug Administration announcement concerning this class of drugs, a study was planned to investigate if ototoxicity occurs in patients using phosphodiesterase 5 inhibitor for erectile dysfunction.

    Methods:

    Eighteen patients with erectile dysfunction who had been using phosphodiesterase 5 inhibitor were included in the study. Audiometric tests were performed on all patients, between the frequencies 250 and 16 000 Hz, before and 1, 5 and 72 hours after drug ingestion.

    Results:

    Four patients showed a unilateral threshold decrease compatible with ototoxicity criteria; this change was reversible. A statistically significant difference in pre- versus post-drug hearing thresholds was observed in the right ear at 10 000 Hz (p = 0.008). There were no statistically significant hearing threshold differences at any other frequencies (p > 0.05).

    Conclusion:

    Although temporary ototoxicity was noted in four patients, we could not find any permanent, deleterious effect of phosphodiesterase type 5 inhibitor on hearing thresholds.