This paper discusses the internal dynamics of American trade policy making in the context of the Transatlantic Trade and Investment Partnership (TTIP) negotiations. The author describes the active role interest groups, the U.S. business community, and representatives on both sides of the political spectrum have played in the passing of Transatlantic Partnership Agreement (TPA), the TPP negotiations, and currently the TTIP debate. Lastly, the author lays out the challenges TTIP will continue to face in light of opposition to specific TPP provisions, trans-atlantic disagreement over ISDS and data flows, and the recent presidential elections.