In intertropical Africa, various haematophagous Diptera are considered responsible for the maintenance and spread of cases of cattle trypanosomiasis in regions where tsetse flies are absent. In comparing early observations with the results of two recent tsetse control campaigns, this paper raises the question of whether the role of machanical vectors is as important as that normally attributed to them, and stresses the insufficiency and impressive nature of available information on this important epidemiological problem, which requires much more intensive research.