This chapter describes why the World Trade Organization (WTO) has proven such a great challenge for the representation of women and women’s interests. Some progress has been made since the Aid-for-Trade programme, which cooperates with the WTO, incorporated gender mainstreaming in 2011. This includes the adoption of the 2017 Joint Declaration on Trade and Women’s Economic Empowerment and the inauguration of the WTO Gender Research Hub in 2021. Nevertheless, to date the WTO has lagged behind other international organizations, including organizations of global economic governance, in representing women and their interests. The chapter posits the following reasons in historical context: (i) Women did not ‘get in on the ground floor’ at the WTO; (ii) The locus of power at the WTO rests with the members (exemplified by the requirement for consensus and the ’single undertaking’, the importance of member proposals, and the institutional weakness of the Secretariat); (iii) The relative lateness and weakness of WTO involvement with civil society, compared to other institutions of global economic governance; (iv) The formative clashes during the 1980s and 1990s between gender and trade activism and trade liberalization; (v) The lex specialis nature of the WTO dispute settlement system; (vi) The WTO is primarily a ‘hard-law’ institution.