This chapter focuses on the approach of the Indonesia-based Tanoto Foundation as a Global South-originated philanthropy with a far broader Asian and even global perspective, and on how it leveraged partnerships for impact. Now into its fortieth year of operations, the Tanoto Foundation has shown how philanthropy that is originated in the Global South is able to engage in knowledge exchange via global communities of practice to help create regional platforms to inspire collaboration. The pandemic has illustrated the importance of an evidence-based approach in the Global South whose results can be measured before they are scaled up and where collaboration is critical. Indonesia is a case in point, having suffered from natural disasters in the midst of the pandemic, challenging both humanitarian relief and disaster recovery. To help meet these challenges, the Foundation partnered with local (district) and national (ministry) government bodies, international development organisations, business entities, and philanthropic organisations both local and overseas. Successes in responding to the pandemic included the harmonisation of data-collation methodologies at the national level and the sharing of newly codified knowledge from the Foundation’s work. This chapter details how Tanoto Foundation built its internal institutional capacity, and maximised its impact by leveraging multiple relationships that can amplify resources, capacity, and knowledge.