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2 results

  • Auditory neuropathy in a patient exposed to xylene: case report

  • T H J Draper, D-E Bamiou
  • Journal:
    The Journal of Laryngology & Otology / Volume 123 / Issue 4 / April 2009
    Published online by Cambridge University Press:
    28 April 2008, pp. 462-465
    Print publication:
    April 2009
  • Objective:

    To report the case of an adult patient who developed auditory complaints following xylene exposure, and to review the literature on the effects of solvent exposure on hearing.

    Case report:

    The patient presented with a gradual deterioration in his ability to hear in difficult acoustic environments and also to hear complex sounds such as music, over a 40-year period. His symptoms began following exposure to the solvent xylene, and in the absence of any other risk factor. Our audiological investigations revealed normal otoacoustic emissions with absent auditory brainstem responses and absent acoustic reflexes in both ears, consistent with a diagnosis of bilateral auditory neuropathy. Central test results were also abnormal, indicating possible involvement of the central auditory pathway.

    Conclusions:

    To our knowledge, this is the first report of retrocochlear hearing loss following xylene exposure. The test results may provide some insight into the effect of xylene as an isolated agent on the human auditory pathway.

  • Cardiovascular Reflexes in Monozygotic Twins Discordant for Exposure to Organic Solvents

  • E. Matikainen, J. Juntunen, M. Koskenvuo, M. Antti-Poika, J. Kaprio
  • Journal:
    Acta geneticae medicae et gemellologiae: twin research / Volume 36 / Issue 4 / October 1987
    Published online by Cambridge University Press:
    01 August 2014, pp. 503-507
    Print publication:
    October 1987
    • Article
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  • Eighteen pairs of monozygotic twins discordant for long-term occupational exposure to organic solvents were examined for disturbances of cardiovascular reflexes. All of the subjects were asymptomatic, and considered themselves healthy. No significant differences were observed between the exposed and the nonexposed twins. The finding suggests that occupational solvent exposure at these particular levels is unlikely to cause disturbances of the autonomic nervous function.