The COVID-19 pandemic has proved challenging to states and regional organizations, exposing gaps in political leadership as well as in the preparedness of economic and public healthcare systems. As states and organizations contend with the pandemic, the African Union's response in this regard, thus far, indicates the imperative of enhanced multilateralism. Its response also provides a template for endowing the organization with assertive, binding powers over its member states and, as such, achieving its supranational aspirations. In this respect, this article argues that the African Union's display of progressive internationalism, swiftness of action, agency and legitimacy in combatting the coronavirus pandemic are elements that can be applied in sharpening its processual quest for supranationalism.