Supported polyoxide catalysts on the base of Mo and W, as well as natural Kazakhstan's clays were tested in the process of oxidative conversion of propane and propane-butane mixture. The influence of reaction temperature, contact time, composition and percentage of the active component of catalyst were determined. The important petrochemical products - acetone (500-550°) and acetaldehyde (300-350°) were the main liquid products of reaction on natural Kazakhstan's clays and also on clays modified by Mo, Bi, Cr and Ga ions.