This research examined a potential nuisance aspect of the use of the volatility-reducing agent (VRA) potassium carbonate when combined with glyphosate in spray-tank mixtures. A VRA is now required to be added to dicamba applications to reduce off-target movement from volatility. When no VRA potassium carbonate was added to the spray mixture, there was no pressure buildup. The addition of VRA potassium carbonate plus glyphosate (which lowers the pH) resulted in an observed pressure buildup. Although the gas produced was not identified, it would be expected to be carbon dioxide formed by the dissolution of the carbonate anion from the VRA. Source water pH range from 3.2 to 8.2 had no effect on pressure buildup. Pressure buildup was directly related to water temperature, with a linear response to temperature when the VRA was added last; in contrast, a less direct relationship of temperature to pressure buildup existed at temperatures >30 C when the VRA potassium carbonate was added first. There was no effect on the pressure increase from adding a defoamer or a drift control agent.