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1 results

  • Bioinformatics in otolaryngology research. Part two: other high-throughput platforms in genomics and epigenetics

  • T J Ow, K Upadhyay, T J Belbin, M B Prystowsky, H Ostrer, R V Smith
  • Journal:
    The Journal of Laryngology & Otology / Volume 128 / Issue 11 / November 2014
    Published online by Cambridge University Press:
    17 September 2014, pp. 942-947
    Print publication:
    November 2014
    • Article
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  • Objectives:

    This second segment of the two-part review summarises several modern high-throughput methods in genomics, epigenetics and molecular biology. Many principles from nucleotide sequencing and transcriptomics can be applied to other high-throughput molecular biology techniques. Specifically, this manuscript reviews: array comparative genome hybridisation; single nucleotide polymorphism arrays; microarray technology, used to study epigenetics; and methodology applied in proteomics. Finally, the review describes current methods for the integration of multiple molecular biology platforms.

    Conclusion:

    Progress in treating human disease in general will require close collaboration with experts in bioinformatics. Improved understanding, by clinicians and physician-scientists in our field, of the concepts presented in both parts of this review will advance diagnosis and therapy for diseases of the head and neck.