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1 results

  • Oral squamous cell carcinoma and serum paraoxonase 1

  • Z Boy Metin, S Aydin, M Unur, B Cakmakoglu, B Toptas, G Hafiz, T İsbir
  • Journal:
    The Journal of Laryngology & Otology / Volume 127 / Issue 12 / December 2013
    Published online by Cambridge University Press:
    11 November 2013, pp. 1208-1213
    Print publication:
    December 2013
  • Background:

    Serum paraoxonase 1 is involved in mechanisms that protect cells from oxidative stress damage. This study aimed to investigate the correlation between serum paraoxonase 1 activity and polymorphisms in patients with oral squamous cell carcinoma.

    Methods and materials:

    Fifty-seven patients with oral squamous cell carcinoma and 59 matched healthy controls participated in the study. Serum paraoxonase 1 activity and polymorphisms in blood samples were compared with results for polymerase chain reaction and restriction fragment length polymorphism tests.

    Results:

    Mean serum paraoxonase 1 activity levels were lower in patients than controls (mean ± standard deviation, 21.9 ± 5 units/l and 120.4 ± 2 units/l, respectively) (p = 0.001). The serum paraoxonase 1 192 glutamine polymorphism was more common in patients than controls.

    Conclusion:

    Patients with oral squamous cell carcinoma had significantly lower serum paraoxonase 1 activity levels and a greater prevalence of the serum paraoxonase 1 192 glutamine allele, compared with controls. Serum paraoxonase 1 may play a role in the aetiology of oral squamous cell carcinoma.