Recent research reported synergism between glufosinate plus very low rates of protoporphyrinogen oxidase (PPO)–inhibiting herbicides on select broadleaf weeds. Two field studies, each consisting of four trials, were conducted in 2020 and 2021 in commercial fields with glyphosate-resistant (GR) horseweed in Ontario, Canada. Study 1 evaluated GR horseweed control with glufosinate plus five PPO inhibitors at 5% of the label rate; study 2 evaluated what dose of saflufenacil is needed when co-applied with glufosinate to improve GR horseweed control. In study 1, glufosinate plus very low rates of PPO-inhibiting herbicides provided low GR horseweed control. At site 1, despite the synergistic increase in GR horseweed control with saflufenacil (1.25 g ai ha–1) plus glufosinate (300 g ai ha–1), the level of control did not exceed 42% at 2 and 4 wk after application (WAA); the interaction was additive at 8 WAA. The co-application of glufosinate (300 g ai ha–1) with pyraflufen-ethyl (0.34 g ai ha–1), pyraflufen-ethyl/2,4-D (26.4 g ai ha–1), flumioxazin (5.35 g ai ha–1), fomesafen (12 g ai ha–1), or sulfentrazone (7 g ai ha–1) resulted in an additive interaction for GR horseweed control at 2, 4, and 8 WAA. However, glufosinate plus pyraflufen-ethyl or sulfentrazone was antagonistic at 8 WAA. In study 2, similar doses of saflufenacil were required for 50%, 80%, and 95% GR horseweed control whether glufosinate was included in the mixture or not. Interactions between glufosinate (300 g ai ha–1) plus saflufenacil at 1.56, 3.13, 6.25, and 12.5 g ai ha–1 were antagonistic at 2, 4, and 8 WAA at sites 1, 2, and 3; all other interactions were additive. The results of this research indicate there was little to no benefit of adding very low rates of PPO-inhibiting herbicides to glufosinate to improve GR horseweed control under field conditions.