In this chapter, we discuss the logic and practice of quasi-experimentation. Specifically, we describe four quasi-experimental designs – one-group pretest–posttest designs, non-equivalent group designs, regression discontinuity designs, and interrupted time-series designs – and their statistical analyses in detail. Both simple quasi-experimental designs and embellishments of these simple designs are presented. Potential threats to internal validity are illustrated along with means of addressing their potentially biasing effects so that these effects can be minimized. In contrast to quasi-experiments, randomized experiments are often thought to be the gold standard when estimating the effects of treatment interventions. However, circumstances frequently arise where quasi-experiments can usefully supplement randomized experiments or when quasi-experiments can fruitfully be used in place of randomized experiments. Researchers need to appreciate the relative strengths and weaknesses of the various quasi-experiments so they can choose among pre-specified designs or craft their own unique quasi-experiments.