Field studies were conducted at three locations in Louisiana over two years to evaluate mid-season, foliar-applied acifluorfen, fomesafen, and lactofen for hemp sesbania control in soybean. Acifluorfen and fomesafen were applied POST at 30, 40, 50, 60, 70, 140, and 280 g ai ha–1 and lactofen was applied at 60, 80, 110, and 220 g ai ha–1. The data fit a quadratic model and log transformations were made to determine differences between treatments. Hemp sesbania control was highly correlated with herbicide rate for each herbicide. Averaged over rates of application, acifluorfen and fomesafen provided equivalent control of hemp sesbania, which was greater than that achieved with lactofen. The minimum effective rate of acifluorfen or fomesafen for 80 and 100% control of 50- to 60-cm hemp sesbania was 50 and 140 g ha–1, respectively. The minimum effective lactofen rate to provide at least 80% control was 220 g har–1.