This chapter briefly reviews relevant findings in the schizophrenia-neuroimaging literature and describes those studies that have been done on brain morphology in schizotypy. It discusses how studies of brain morphology may be used to explore alternative models of the relationship between schizotypy and schizophrenia. Examples are provided through preliminary analyses of magnetic resonance imaging (MRI) data that have been collected in laboratory over the last several years. Alternative strategies, including the study of schizotypal-proneness among normal controls, and its relationship to brain morphology, are also presented. Finally, the limitations of the approach and implications for research are discussed. Phrenology, the study of the contours of the skull, was pioneered by Francis Gall in the 1800s based on his theory that the skull's conformation would mirror the underlying brain surface, and prove to be related to specific mental abilities and personality characteristics.