We consider an inventory system to which arrival of items stored is a renewal process, and the demand is a Poisson process. Items stored have finite and fixed lifetimes. The blood-bank model inspired this study. Three models are studied. In the first one, we assume that each demand is for one unit and unsatisfied demands leave the system immediately. Using results on this model one is able to study a model in which arrival of items is Poisson but demands are for several units, and a model in which demands are willing to wait. We compute ergodic limits for the lost demands and the lost items processes and the limiting distribution of the number of items stored. The main tool in this analysis is an analogy to M/G/1 queueing systems with impatient customers.