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3 results

  • Perioral gustatory sweating: case report

  • S C Käyser, K J A O Ingels, F J A van den Hoogen
  • Journal:
    The Journal of Laryngology & Otology / Volume 126 / Issue 5 / May 2012
    Published online by Cambridge University Press:
    02 March 2012, pp. 532-534
    Print publication:
    May 2012
  • Objective:

    Presentation of a case of perioral Frey syndrome.

    Design:

    Case report.

    Subject:

    A 72-year-old woman with hyperhidrosis around the mouth and chin.

    Results:

    This patient suffered from bilateral perioral gustatory sweating following a mandibular osteotomy; such a case has not previously been described. Possible pathophysiological hypotheses are discussed in relation to the anatomy and innervation of the salivary glands.

    Conclusion:

    Perioral gustatory sweating is a rare complication of osteotomy.

  • Botulinum toxin A for quality of life improvement in post-parotidectomy gustatory sweating (Frey's syndrome)

  • D M Hartl, M Julieron, A-M LeRidant, F Janot, P Marandas, J-P Travagli
  • Journal:
    The Journal of Laryngology & Otology / Volume 122 / Issue 10 / October 2008
    Published online by Cambridge University Press:
    21 February 2008, pp. 1100-1104
    Print publication:
    October 2008
  • Objective:

    To measure patient-reported quality of life before and after botulinum toxin A treatment of post-parotidectomy Frey's syndrome (gustatory sweating).

    Patients and methods:

    A questionnaire concerning functional, social and emotional aspects of Frey's syndrome (14 questions, with responses on a zero to three point scale) was administered to 17 patients (13 women and four men) before and one month after intradermal injection of botulinum toxin A. Parotidectomy had been performed one to 19 years previously, for benign (n = 10) or malignant (n = 7) tumours, with gustatory sweating occurring a median of 15 months after surgery (range: one month to 14 years). Pre- and post-treatment quality of life scores were compared using Wilcoxon's test (p < 0.05).

    Results:

    Patients' reported functional quality of life improved significantly (p = 0.0004). Their social and emotional scores were not significantly modified (p = 0.155 and 0.142, respectively). Seven patients (41 per cent) found the injections painful, but all patients said that the effects were beneficial, that they would undergo new injections if necessary and that they would recommend this treatment to other patients. The benefit lasted over 1.5 years for 60 per cent of patients. No correlation was found between duration of the effect and the extent of parotidectomy (p = 0.067).

    Conclusions:

    Botulinum toxin A significantly improved patients' functional quality of life, without significant improvement in their social or emotional quality of life, according to our questionnaire results. The duration of the effect was longer than the reported physiological effect of botulinum toxin A on acetylcholine receptors.

  • The bullet that hit a nerve: the history of Lucja Frey and her syndrome

  • Nicola Jacobsen, Claire Hopkins
  • Journal:
    The Journal of Laryngology & Otology / Volume 120 / Issue 3 / March 2006
    Published online by Cambridge University Press:
    07 February 2006, pp. 178-180
    Print publication:
    March 2006

  • Duphenix first described gustatory sweating in 1757. The underlying pathogenesis was not appreciated until 1923, when Lucja Frey, a Polish neurologist, observed the phenomenon in a Polish soldier with an infected bullet wound in the parotid gland and suggested that the auriculo-temporal nerve played a role.

    Lucja Frey was born in Lwów, Poland, in 1889 and began her medical studies in Lwów before moving to Warsaw to work as a neurologist. She amassed a total of 43 publications on various neurological topics over her career. Unfortunately, during the Second World War she was enlisted into the Lwów ghetto, where she worked until her death in 1943.

    We present the history of Frey's syndrome, particularly the life of Lucja Frey and the syndrome she described.