Cowpea bean (Vigna unguiculata) is usually submitted to pre-harvest burndown with herbicides aiming to an early harvest. We aimed to quantify the residues of paraquat, diquat, glufosinate-ammonium and glyphosate in cowpea grains subjected to two timings of pre-harvest burndown. Three identical experiments were installed in Dourados (Lat. 22° S), Sinop (Lat. 11° S) and Teresina (Lat. 05° S), Brazil, comprising the pre-harvest burndown of cowpea bean with these herbicides, applied either with 50 or 75% of the pods dry and ready for harvest. As hotter and drier the location as slower the herbicide dissipation. Glyphosate should not be used for pre-harvest burndown of cowpea. Herbicide residues were above the maximum levels stated by the Brazilian legislation when applied with 50% dry pods. Burndown herbicides aiming to speed harvest should be applied with at least 75% dry pods in cowpea to ensure safe herbicide residue levels in grains.

It is now accepted that the way our health evolves with aging is intimately linked to the quality of our early life. The present review highlights the emerging data of Developmental Origins of Health and Disease field on developmental disruption by toxicants and their subsequent effect on type 2 diabetes. We report adverse neonatal effects of several food contaminants during pregnancy and lactation, among them bisphenol A, chlorpyrifos, perfluorinated chemicals on pancreas integrity and functionality in later life. The described alterations, in conjunction with disruption of β cell mass in early life, can lead to dysregulation of glucose metabolism, insulin synthesis, which facilitates the development of insulin resistance and progression of diabetes in the adult. Despite limited and often inconclusive epidemiologic and experimental data, more recent data clearly show that infants appear to be at increased risk of type 2 diabetes in later life. This may be a result of continued exposure to chemical food contaminants during the critical window of pancreas development. In societies already burdened with increased incidence of non-communicable chronic diseases, there is a clear need for information regarding the potential harmful effects of chemical food contaminants on adult health diseases.