The 1926 International Sanitary Convention, which laid out requirements for port sanitation and quarantine in order to limit the spread of diseases internationally, changed the way that the world approached international epidemic control. The 1926 convention is notable for two reasons: the increased reliance on epidemic intelligence rather than quarantine, and the splitting of the world into a series of formalized regional networks under the auspices of a global agreement. This article explores the creation and the limits of this system as a window into shifting understandings of disease and international relations in the interwar era, arguing that sanitary spheres of influences were shaped by, but not entirely dependent on, political spheres of influence.