Duration and spectrum of preemergence (PRE) weed control following isoxaben application at 0.56, 0.84, and 1.12 kg ai/ha in spring, fall, or spring plus fall (double) application were evaluated by field experiments. Residual activity of isoxaben was assessed by monitoring weed counts at two locations for 12 mo after treatment (MAT). Buckhorn plantain and dandelion control from spring-applied isoxaben at 1.12 kg/ha was > 90% at 4 MAT in Blacksburg but dropped to < 51% at 12 MAT. Isoxaben at 1.12 kg/ha applied in fall provided ≥ 90% control of buckhorn plantain for 8–9 MAT, with control ranging from 69 to 91% at approximately 12 MAT. Dandelion control with fall-applied isoxaben at 1.12 kg/ha ranged from 60 to 75%, 8–9 MAT. Fall application of 1.12 kg/ ha isoxaben at Virginia Beach controlled henbit and cornspeedwell for 2–3 MAT. Multiple applications of isoxaben improved weed control at Virginia Beach, but results were inconclusive at Blacksburg. In comparison, oxadiazon controlled white sweet clover and dandelion for 1 MAT following spring application in Blacksburg, but < 65% broadleaf control was observed at 4 MAT. Broadleaf weed control following single application of oxadiazon at 3.36 kg/ha was < 60% at 9 MAT Poor weed control resulted from spring applications of isoxaben and oxadiazon when a 25-cm precipitation occurred within 2 wk after application in one study.