Identified by Immanuel Wallerstein as the first true hegemon, the Dutch Empire dominated maritime commerce in the seventeenth century. Amsterdam emerged as the world’s alpha city, the site of the first true global multinational corporations. In tandem with corporate activities including the founding of New York City, Cape Town, and Jakarta, Amsterdam established the first modern stock market. It also solidified the North–South power imbalance. European powers extracted the labor and raw materials of far-flung colonies, refining them at higher value. The under-populated Dutch Empire relied on forced migration and slave labor to produce valuable goods such as sugar, tobacco, and spices. This chapter traces the emergence of a city network in the Low Countries that prefigured its independence from Spain, and the construction of its own imperial network. The Dutch city network expanded globally, establishing critical nodes in West Africa, the Americas, the Caribbean, and Asia to manage the flow of resources and labor. Amsterdam’s place at the top of the world city hierarchy led to rising inequality, prefiguring modern urban “command centers.”