Field studies were conducted during the 2004 and 2005 growing seasons to evaluate the effects of various herbicides on smellmelon control and soybean yield response. Pendimethalin applied pre-emergence (PRE) alone controlled smellmelon no better than 70%, whereas pendimethalin plus imazethapyr, flumioxazin, or cloransulam applied PRE provided almost complete smellmelon control (99%). Pendimethalin applied PRE followed by acifluorfen applied early postemergence (EPOST) provided similar control. Glyphosate alone applied late postemergence (LPOST) provided complete control (100%), and pendimethalin followed by glyphosate applied EPOST controlled smellmelon at least 95%. Most herbicides increased soybean yield over the nontreated check.