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2 results

  • Immunophenotypes of the palatal tonsil lymphocytes in Cowden's disease

  • Yasuyuki Kimura, Takaki Miwa, Mituru Furukawa
  • Journal:
    The Journal of Laryngology & Otology / Volume 106 / Issue 7 / July 1992
    Published online by Cambridge University Press:
    29 June 2007, pp. 640-642
    Print publication:
    July 1992

  • Cowden's disease is characterized by multiple hamartomas and neoplasias of ectodermal, mesodermal and endodermal origin. A case of a 22-year-old man suffering from nocturnal dyspnoea is reported. The patient had a large number of hyperkeratotic, lichenoid papules, scattered over the right side of the trunk, back and palm. In his oral cavity, papules were present on the gingiva and hard palate. The patient was operated on for tonsillar hypertrophy and for excluding the possibility of malignant lymphoma. An examination of immunophenotypes of the palatal tonsil lymphocytes revealed B-cell proliferation and poly-clonal immunoglobulin.