The concentration of radiocarbon (14C) differs between ocean and atmosphere. Radiocarbon determinations from samples which obtained their 14C in the marine environment therefore need a marine-specific calibration curve and cannot be calibrated directly against the atmospheric-based IntCal20 curve. This paper presents Marine20, an update to the internationally agreed marine radiocarbon age calibration curve that provides a non-polar global-average marine record of radiocarbon from 0–55 cal kBP and serves as a baseline for regional oceanic variation. Marine20 is intended for calibration of marine radiocarbon samples from non-polar regions; it is not suitable for calibration in polar regions where variability in sea ice extent, ocean upwelling and air-sea gas exchange may have caused larger changes to concentrations of marine radiocarbon. The Marine20 curve is based upon 500 simulations with an ocean/atmosphere/biosphere box-model of the global carbon cycle that has been forced by posterior realizations of our Northern Hemispheric atmospheric IntCal20 14C curve and reconstructed changes in CO2 obtained from ice core data. These forcings enable us to incorporate carbon cycle dynamics and temporal changes in the atmospheric 14C level. The box-model simulations of the global-average marine radiocarbon reservoir age are similar to those of a more complex three-dimensional ocean general circulation model. However, simplicity and speed of the box model allow us to use a Monte Carlo approach to rigorously propagate the uncertainty in both the historic concentration of atmospheric 14C and other key parameters of the carbon cycle through to our final Marine20 calibration curve. This robust propagation of uncertainty is fundamental to providing reliable precision for the radiocarbon age calibration of marine based samples. We make a first step towards deconvolving the contributions of different processes to the total uncertainty; discuss the main differences of Marine20 from the previous age calibration curve Marine13; and identify the limitations of our approach together with key areas for further work. The updated values for ΔR, the regional marine radiocarbon reservoir age corrections required to calibrate against Marine20, can be found at the data base http://calib.org/marine/.

Research was conducted to determine the utility of a single, temperature-independent Weibull function for describing cumulative seed germination under several temperature regimes with 14 sets of weed and crop seed germination data. A modified cumulative Weibull function was derived to distribute germination times for individuals within the population and distributed the occurrence of germination given ample sample size and appropriate sample interval. The descriptive and predictive attributes of the stochastic model component are well suited for incorporation into seed germination models and are likely applicable to models to predict distribution of times for other developmental processes of plants.

The Chemical Movement through Layered Soils (CMLS) model was modified and combined with the USDA-SCS State Soil Geographic Data Base (STATSGO) and Montana Agricultural Potentials System (MAPS) digital databases to assess the likelihood of groundwater contamination from selected herbicides in Teton County, MT. The STATSGO and MAPS databases were overlaid to produce polygons with unique soil and climate characteristics and attribute tables containing only those data needed by the CMLS model. The Weather Generator (WGEN) computer simulation model was modified and used to generate daily precipitation and evapotranspiration values. A new algorithm was developed to estimate soil carbon as a function of soil depth. The depth of movement of the applied chemicals at the end of the growing season was estimated with CMLS for each of the soil series in the STATSGO soil mapping units and the results were entered into ARC/INFO to produce the final hazard maps showing best, weighted average, and worst case results for every unique combination (polygon) of soil mapping unit and climate. County weed infestation maps for leafy spurge and spotted knapweed were digitized and overlaid in ARC/INFO with the CMLS model results for picloram to illustrate how the results might be used to evaluate the threat to groundwater posed by current herbicide applications.

The ARS Pesticide Properties Database (PPD) is a compendium of chemical and physical properties of a collection of widely used pesticides. At present, there are 92 compounds in the database and we have focused on 19 of the most important properties impacting on groundwater and atmospheric quality. The PPD relies upon experimentally determined data points. With the help of the National Agricultural Chemicals Association (NACA) we have been communicating directly with manufacturers to obtain the original experimental data with which they characterize pesticide properties and fulfill requirements for federal and state regulations. This provides the basis for the PPD which is augmented with data from the scientific literature. Features of the PPD are: 1. 19 parameters are provided for each pesticide. 2. References are given for all data. 3. When there are several values for a given property, all are cited. 4. All data have been verified and provide the latest, most reliable figures available.

The volume and surface area of glacial Lake Agassiz varied considerably during its 4000-year history. Computer models for seven stages of Lake Agassiz were used to quantify these variations over the lake's early history, between about 11,000 and 9300 14C yr B.P. (ca. 13,000 to 10,300 cal yr B.P.). Just after formation of the Herman strandlines (ca. 11,000 14C yr B.P.), the volume of Lake Agassiz appears to have decreased by >85% as a consequence of the abrupt rerouting of overflow to its eastern outlet from its southward routing into the Mississippi River basin. This drainage released about 9500 km3 of water into the North Atlantic Ocean via the Great Lakes and Gulf of St. Lawrence. Following closure of this eastern routing of overflow, the lake reached its maximum size at about 9400 14C yr B.P. with an area of >260,000 km2 and a volume of >22,700 km3. A second major reduction in volume occurred shortly after that, when its volume decreased >10% following the opening of the Kaiashk outlet to the east into the Great Lakes, and 2500–7000 km3 of water was released into the North Atlantic Ocean. These discharges may have affected ocean circulation and North Atlantic Deep Water production.

We evaluated the contributions of somatic and dendritic impulses to the receptive field dimensions of amacrine cells in the amphibian retina. For this analysis, we used the NEURON simulation program with a multicompartmental, multichannel model of an On-Off amacrine cell with a three-dimensional structure obtained through computer tracing techniques. Simulated synaptic inputs were evenly spaced along the dendritic branches and organized into eight annuli of increasing radius. The first set of simulations activated each ring progressively to simulate an area summation experiment, while a second approach activated each annulus individually. Both sets of simulations were done with and without the presence of Na channels in the dendrites and soma. Unexpectedly, the receptive field dimensions observed in the area summation simulations was often smaller than that predicted from the summation of the annular simulations. Collisions of action potentials moving in opposite directions in the dendrites largely accounted for this contraction in receptive field size for the area summation studies. The presence of dendritic Na channels increased the size of the receptive field beyond that achieved in their absence and allowed the physiological size of the receptive field to approximate the physical dimensions of the dendritic tree. This receptive field augmentation was the result of impulse generating ability in the dendrites which enhanced the signal observed at the soma. These simulations provide a plausible mechanistic explanation for physiological recordings from amacrine cells that show similar phenomena.

more than 30 years ago, fontan and baudet proposed bypass of a dysfunctional right ventricle by connecting the pulmonary arteries directly to the right atrium, the so-called atriopulmonary anastomosis. since then, much experience has been accrued in the field of the functionally univentricular circulation. the proposed connections have been subjected to several modifications, aiming towards minimizing the losses of energy in the cavopulmonary system, and thereby improving the clinical outcomes. a remarkable improvement was achieved with the introduction of the concept of the total cavopulmonary connection, specifically the combination of a bi-directional glenn anastomosis with a tubular intracardiac extension from the inferior caval venous to the pulmonary arteries. this design was shown to avoid the dissipation of energy associated with the swirling patterns seen in the traditional atrio-pulmonary anastomosis.

among the operations which lead to a partial rerouting of the systemic venous return into the pulmonary arteries, the bidirectional cavopulmonary anastomosis is frequently utilised in the staged surgical management of patients with functionally univentricular hearts. whereas some surgeons insist on closing any other source of pulmonary blood flow while performing a bidirectional cavopulmonary anastomosis, others maintain patency of either a stenosed native pulmonary outflow tract, or of a systemic-to-pulmonary arterial shunt. it remains controversial as to whether an additional source of pulmonary arterial blood flow can safely and usefully be left at the time of the bidirectional cavopulmonary anastomosis to increase systemic saturation, or whether it should be eliminated to reduce the volume load on the ventricle.

the norwood procedure involves three separate stages of operative corrections. the first stage involves re-fashioning the pulmonary trunk into a neo-aorta so that it is possible to establish an unrestricted systemic circulation. an interpositional, or systemic-to-pulmonary arterial, shunt is then created between the neo-aorta and the pulmonary arteries to allow pulmonary perfusion and gas exchange. two of the available options for the systemic-to-pulmonary shunt are the central shunt and the right modified blalock-taussig shunt. in the setting of a central shunt, pulmonary perfusion is derived from a conduit placed between the pulmonary arterial bed and the neo-aorta whereas, in the modified blalock-taussig shunt, the conduit is interposed between one of the pulmonary arteries and the brachiocephalic artery. in subsequent stages, pulmonary perfusion is provided directly by deoxygenated blood. this is achieved by connecting, first, the superior caval vein, and then the inferior caval vein, to the pulmonary arteries. it is usually during the second stage that the systemic-to-pulmonary shunt is removed.

This paper gives a detailed presentation of a computer model for evaluating the cost-effectiveness (CE) of hormone replacement therapy (HRT), describing the model's design, structure, and data requirements. The model needs data specified for costs, quality of life, risks, and mortality rates. As an illustration, the CE of HRT in Sweden is calculated. Two treatment strategies are evaluated for asymptomatic women: estrogen-only therapy and estrogen combined with a progestin. The model produces similar results compared with earlier studies. The CE ratios improve with the size of the risk reduction and generally with age. Further, estrogen-only therapy is associated with a lower cost per gained effectiveness unit compared with combined therapy. Uncertainty surrounding the long-term effects of HRT means that the CE estimates should be interpreted carefully. The model permits the inclusion of indirect costs and costs in added life-years, allowing the analysis to be made from a societal perspective, which is an improvement relative to previous studies.