Cognitive theories of depression contend that biased cognitive information processing plays a causal role in the development of depression. Extensive research shows that deeper processing of negative and/or shallower processing of positive self-descriptors (i.e., negative and positive self-schemas) predicts current and future depression in adults and children. However, the neural correlates of the development of self-referent encoding are poorly understood. We examined children's self-referential processing using the self-referent encoding task (SRET) collected from 74 children at ages 6, 9, and 12; around age 10, these children also contributed structural magnetic resonance imaging data. From age 6 to age 12, both positive and negative self-referential processing showed mean-level growth, with positive self-schemas increasing relatively faster than negative ones. Further, voxel-based morphometry showed that slower growth in positive self-schemas was associated with lower regional gray matter volume (GMV) in ventrolateral prefrontal cortex (vlPFC). Our results suggest that smaller regional GMV within vlPFC, a critical region for regulatory control in affective processing and emotion development, may have implications for the development of depressogenic self-referential processing in mid-to-late childhood.

This prospective study provided a direct comparison of French and American samples concerning a cognitive diathesis for depression. Using the Experience Sampling Method and identical measures across sites, subjects were signaled five times daily by electronic devices to provide in vivo reports of negative events, attributions, and depressed moods. After controlling for effects associating clinical and demographic variables, and despite differences attributable to national origin, attributional style emerged as a highly significant predictor of the numerous specific attributions made to negative events within the course of daily life. However, consistent with the cognitive mediation hypothesis, attributional style did not directly explain depression levels. The results are discussed in terms of the predictive power of cognitive and personality assessments in understanding the day-to-day experience of depression.

The present study examined the dysfunctional attitudes and the personality styles of 40 psychiatric outpatients with obsessive-compulsive disorder (OCD) and compared them to 33 outpatients with major depressive disorder (MDD) and 41 healthy controls (HC). Scores on Beck's Depression Inventory (BDI), Dysfunctional Attitude Scale (DAS), and Sociotropy-Autonomy Scale (SAS) were obtained for the three groups. Based on previous research it was predicted that higher levels of sociotropy subscales S 1 (concern about disapproval), and S 2 (attachment/separation concerns) would be specifically related to the diagnosis of OCD after controlling for differences in demographic variables and other psychiatric diagnoses. These hypotheses were confirmed. Significantly lower scores on subscale A 3 (solitary pursuits) was also found specifically related to OCD diagnoses. Higher scores on DAS and lower scores on autonomy subscale A 1 (independent achievement) were found to be particularly related to MDD. Implications of these findings for a cognitive model of the development of OCD are discussed.