Building on recent research into the religious aspects of the Cold War and the humanitarian efforts of the American Young Men’s Christian Association (YMCA) in early twentieth-century Europe, this article locates the historical origins of religious anti-communism in late imperial Russian reactions to the revolution of 1905–07. It explores the interactions of Russian Orthodox Christian intellectuals, especially Nikolai Aleksandrovich Berdyaev, with prominent YMCA leaders such as Donald A. Lowrie and Paul B. Anderson, both of whom were mainline Protestants. Using Russian and US archives, the article documents the networks and mechanisms through which Berdyaev influenced his YMCA contacts. It shows that he shaped their efforts to fight communism in the interwar period and early Cold War through the promotion of religious values, or what Anderson referred to as ‘a Christian solution to international tension’. This concept was derived from early twentieth-century Russian ideas about the opposition between Christianity and ‘nihilism’ or ‘humanism’ as integral worldviews.