In this investigation, the magnetohydrodynamic pulsatile flow of Casson nanofluid through a vertical channel embedded in porous medium with thermal radiation and heat generation/absorption has been analyzed using Buongiorno model. The influence of viscous and Joules dissipations are taken into account. The governing coupled partial differential equations are reduced to ordinary differential equations using perturbation scheme and then solved numerically by using Runge-Kutta fourth order technique along with shooting method. The impact of various emerging parameters on velocity, temperature, nanoparticles concentration, Nusselt number and Sherwood number distributions are analyzed in detail. Analysis indicates that the temperature distribution increases for a given increase in Brownian motion parameter and thermophoresis parameter, while it decreases with an increase in Hartmann number. Further, the nanoparticles concentration distribution decreases with an increase in the chemical reaction parameter and the Lewis number, while it increases for a given increase in the Brownian motion parameter.