In order to enhance the power-load of two-cell stimulated Brillouin scattering (SBS) system, methods of using different media and mixed medium are proposed. In theory, the amplification function of two-cell system of different medium with close vicinity in the Brillouin frequency shift (BFS) is analyzed. Also the variation of BFS of the mixed medium with the mixing ratio is analyzed. In the two-cell SBS system pumped by Q-switched Nd:YAG laser, the SBS system performance characteristics are investigated with different media and mixed medium. The experimental results indicate that the Stokes can be sufficiently amplified by choosing different medium with close vicinity in the BFS; the power-load performance is enhanced as well as the maximum amplification efficiency the Stokes by choosing mixed medium.