Machine learning methods have been used in identifying omics markers for a variety of phenotypes. We aimed to examine whether a supervised machine learning algorithm can improve identification of alcohol-associated transcriptomic markers. In this study, we analysed array-based, whole-blood derived expression data for 17 873 gene transcripts in 5508 Framingham Heart Study participants. By using the Boruta algorithm, a supervised random forest (RF)-based feature selection method, we selected twenty-five alcohol-associated transcripts. In a testing set (30 % of entire study participants), AUC (area under the receiver operating characteristics curve) of these twenty-five transcripts were 0·73, 0·69 and 0·66 for non-drinkers v. moderate drinkers, non-drinkers v. heavy drinkers and moderate drinkers v. heavy drinkers, respectively. The AUC of the selected transcripts by the Boruta method were comparable to those identified using conventional linear regression models, for example, AUC of 1958 transcripts identified by conventional linear regression models (false discovery rate < 0·2) were 0·74, 0·66 and 0·65, respectively. With Bonferroni correction for the twenty-five Boruta method-selected transcripts and three CVD risk factors (i.e. at P < 6·7e-4), we observed thirteen transcripts were associated with obesity, three transcripts with type 2 diabetes and one transcript with hypertension. For example, we observed that alcohol consumption was inversely associated with the expression of DOCK4, IL4R, and SORT1, and DOCK4 and SORT1 were positively associated with obesity, and IL4R was inversely associated with hypertension. In conclusion, using a supervised machine learning method, the RF-based Boruta algorithm, we identified novel alcohol-associated gene transcripts.

People rely extensively on online social networks (OSNs) in Africa, which aroused cyber attackers’ attention for various nefarious actions. This global trend has not spared African online communities, where the proliferation of OSNs has provided new opportunities and challenges. In Africa, as in many other regions, a burgeoning black-market industry has emerged, specializing in the creation and sale of fake accounts to serve various purposes, both malicious and deceptive. This paper aims to build a set of machine-learning models through feature selection algorithms to predict the fake account, increase performance, and reduce costs. The suggested approach is based on input data made up of features that describe the profiles being investigated. Our findings offer a thorough comparison of various algorithms. Furthermore, compared to machine learning without feature selection and Boruta, machine learning employing the suggested genetic algorithm-based feature selection offers a clear runtime advantage. The final prediction model achieves AUC values between 90% and 99.6%. The findings showed that the model based on the features chosen by the GA algorithm provides a reasonable prediction quality with a small number of input variables, less than 31% of the entire feature space, and therefore permits the accurate separation of fake from real users. Our results demonstrate exceptional predictive accuracy with a significant reduction in input variables using the genetic algorithm, reaffirming the effectiveness of our approach.