Field studies were conducted to determine if oxyfluorfen alone or combined with other herbicides could be applied between black polyethylene mulch without injuring muskmelon. Oxyfluorfen at rates up to 1.1 kg ai/ha did not injure muskmelon provided adequate rain or irrigation occurred to incorporate the oxyfluorfen thereby minimizing vapors that could injure muskmelon. Using this practice, muskmelon yields from oxyfluorfen-treated plots were the same as yields from untreated cultivated plots.