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2 results

  • Evolutionary synthesis of kinematic mechanisms

  • Hod Lipson
  • Journal:
    AI EDAM / Volume 22 / Issue 3 / August 2008
    Published online by Cambridge University Press:
    12 June 2008, pp. 195-205
    • Article
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  • This paper discusses the application of genetic programming to the synthesis of compound two-dimensional kinematic mechanisms, and benchmarks the results against one of the classical kinematic challenges of 19th century mechanical design. Considerations for selecting a representation for mechanism design are presented, and a number of human-competitive inventions are shown.

  • Screening and synthesis: high throughput technologies applied to parasitology

  • R. E. MORGAN, N. J. WESTWOOD
  • Journal:
    Parasitology / Volume 128 / Issue S1 / October 2004
    Published online by Cambridge University Press:
    12 May 2005, pp. S71-S79

  • High throughput technologies continue to develop in response to the challenges set by the genome projects. This article discusses how the techniques of both high throughput screening (HTS) and synthesis can influence research in parasitology. Examples of the use of targeted and phenotype-based HTS using unbiased compound collections are provided. The important issue of identifying the protein target(s) of bioactive compounds is discussed from the synthetic chemist's perspective. This article concludes by reviewing recent examples of successful target identification studies in parasitology.