Carrier water quality is an important consideration for herbicide efficacy. Field and greenhouse studies were conducted from 2021 to 2023 to evaluate the effect of carrier water pH and hardness on imazapic efficacy for sicklepod control in peanut crops. In separate field experiments imazapic was applied postemergence at 0.071 kg ai ha−1 with carrier water pH levels of 5, 6, 7, 8, or 9; and hardness levels of 0 (deionized water), 100, 200, 400, or 500 mg L−1 of CaCO3 equivalent. In greenhouse experiments, imazapic was applied to sicklepod that was either 10 cm, 15 cm, or 20 cm tall at similar carrier water pH levels and hardness levels of 0, 100, 200, 400, or 800 mg L−1 of CaCO3. In the field study, sicklepod control, density, and biomass reductions were lower with carrier water pH 5 or 9 compared with pH 7. In the greenhouse study, control was not different among carrier water pH levels when imazapic was applied to 10-cm-tall sicklepod; however, when applied to 15- or 20-cm-tall sicklepod, control was at least 25% greater with acidic (pH 5) compared to alkaline (pH 9) carrier water. Results from the field study showed that carrier water hardness ≤500 ppm did not reduce the efficacy of imazapic to control sicklepod. In the greenhouse study, regardless of sicklepod height, carrier water hardness of 800 mg L−1 reduced sicklepod control by 15% and biomass reduction by 17% compared with deionized water (pH 7). The effects of carrier water pH and hardness on imazapic efficacy did not compromise peanut yield in the field study. However, this study indicates that both acidic and alkaline carrier water pH and hardness (800 mg L−1 CaCO3 L−1) have the potential to reduce imazapic efficacy on sicklepod, and appropriate spray solution amendments maybe be needed to maintain optimum efficacy.